| 简体中文 | ||
| 同义词 | 线粒体样 | mitochondria-like |
| 描述 | 分裂间期细胞胞浆内呈现粗颗粒样荧光。 |
Coarse granular filamentous staining extending throughout the cytoplasm. e.g. anti-mitochondrial antibodies. |
| 抗原相关性 | PDC-E2/M2, BCOADC-E2, OGDC-E2, E1α PDC亚单位, E3BP/蛋白 X | PDC-E2/M2, BCOADC-E2, OGDC-E2, E1α subunit of PDC, E3BP/protein X |
►常见于原发性胆汁性胆管炎，但也可在系统性硬化症中检出，包括原发性胆汁性胆管炎-系统性硬化症重叠综合征、原发性胆汁性胆管炎-干燥综合征重叠综合征 (93-97)
►如临床上疑似为原发性胆汁性胆管炎，建议进行AMA的后续检测，该检测历来是用IIFA法在啮齿类动物组织 (肝、胃、肾)上进行；这些自身抗体主要针对PDH复合物，尤其是E2亚基 (PDH-E2)；抗原包含于疾病特异性免疫检测试剂中 (即，肝病谱*)以及一些常规的ENA抗体谱中 (93，94)
►其余所识别的抗原包括PDH的E1α 和 E1β亚基、PDH的E3结合蛋白和2-OGDC；这些抗原仅包含于扩展的疾病特异性免疫检测试剂中 (即，扩展的肝病谱*) (93，94)
*肌炎谱、系统性硬化症谱和 (扩展的) 肝病谱可能仅限于专业临床实验室应用。
► Commonly found in PBC, but also detected in SSc, including PBC-SSc overlap syndrome and PBC-SjS overlap syndrome (93–97)
► If PBC is clinically suspected it is recommended to perform a follow-up test for AMA, historically detected by IIFA on rodent tissue (liver, stomach, kidney); these autoantibodies are primarily directed to the PDH complex, and in particular the E2-subunit (PDH-E2); the antigen is included in disease specific immunoassays (i.e., liver profile*) as well as in some routine ENA profiles (93, 94)
► Additional antigens recognized include the E1α and E1β subunits of PDH, the E3-binding protein of PDH, and the 2-OGDC; these antigens are only included in extended disease specific immunoassays (i.e., extended liver profile*) (93, 94)
*Availability of the inflammatory myopathy profile, the SSc profile and the (extended) liver profile may be limited to specialty clinical laboratories.
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