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AC-25-纺锤体型

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描述

有丝分裂细胞中的纺锤丝呈锥形染色，包括NuMA类和非NuMA模式，NuMA类另有明显的细胞核斑点染色。此处仅显示非NuMA模式，NuMA类可见于其相应组别。

 The spindle fibers between the poles are stained in mitotic cells, associated with cone-shaped decoration of the mitotic poles. Spindle fibers cover both NuMA-like and non-NuMA patterns. NuMA-like pattern has associated distinct nuclear speckles. Only non-NuMA patterns are shown here while NuMA-like patterns are shown in the NuMA-like group.
抗原相关性 HsEg5 (纺锤体驱动蛋白) HsEg5

  • 临床相关性

    一级信息

    关于临床相关性和缩写列表

    Clinical Relevance

    First level information

    About Clinical Relevance & List of Abbreviations


  • ►AC-25核型对任何疾病的阳性预测价值都很低 (109) 

    ►在常规血清学诊断中非常少见 (109) 

    ►所识别的抗原包括HsEg5；针对该自身抗体或其他纺锤状纤维靶抗原的特异性免疫检测试剂目前尚未商品化 (110,111)



    ► The AC-25 pattern has low positive predictive value for any disease (109)

    ► Found very infrequently in a routine serology diagnostic setting (109)

    ► Antigen recognized includes HsEg5; specific immunoassays for this autoantibody, or other spindle fiber targets, are currently not commercially available (110, 111)

  • 一级信息参考文献
    First level information references


  • 109. Mozo L, Gutiérrez C, Gómez J. Antibodies to mitotic spindle apparatus: clinical significance of NuMA and HsEg5 autoantibodies. J Clin Immunol 2008;28:285–90.

    110. Whitehead CM, Winkfein RJ, Fritzler MJ, et al. The spindle kinesin-like protein HsEg5 is an autoantigen in systemic lupus erythematosus. Arthritis Rheum 1996;39:1635–42.

    111. Szalat R, Ghillani-Dalbin P, Jallouli M, et al. Anti-NuMA1 and anti-NuMA2 (anti-HsEg5) antibodies: clinical and Immunological features: a propos of 40 new cases and review of the literature. Autoimmun Rev 2010;9:652–6.



    109. Mozo L, Gutiérrez C, Gómez J. Antibodies to mitotic spindle apparatus: clinical significance of NuMA and HsEg5 autoantibodies. J Clin Immunol 2008;28:285–90.

    110. Whitehead CM, Winkfein RJ, Fritzler MJ, et al. The spindle kinesin-like protein HsEg5 is an autoantigen in systemic lupus erythematosus. Arthritis Rheum 1996;39:1635–42.

    111. Szalat R, Ghillani-Dalbin P, Jallouli M, et al. Anti-NuMA1 and anti-NuMA2 (anti-HsEg5) antibodies: clinical and Immunological features: a propos of 40 new cases and review of the literature. Autoimmun Rev 2010;9:652–6.

  • 二级信息
    Second level information


  • ►虽然AC-25与确定的自身免疫疾病无关，但与HsEg5的反应性更常见于干燥综合征和系统性红斑狼疮 (8,9)

    注：HsEg5的特异性免疫检测试剂目前尚未商品化。



    ► While AC-25 is not associated with a defined autoimmune disease, reactivity with HsEg5 is more commonly found in SjS and SLE (8, 9)

    Note: Specific immunoassays for HsEg5 are currently not commercially available.

  • 二级信息参考文献
    Second level information references


  • 8. Whitehead CM, Winkfein RJ, Fritzler MJ, et al. The spindle kinesin-like protein HsEg5 is an autoantigen in systemic lupus erythematosus. Arthritis Rheum 1996;39:1635-42.

    9. Szalat R, Ghillani-Dalbin P, Jallouli M, et al. Anti-NuMA1 and anti-NuMA2 (anti-HsEg5) antibodies: Clinical and immunological features: A propos of 40 new cases and review of the literature. Autoimmun Rev 2010;9:652-6.



    8. Whitehead CM, Winkfein RJ, Fritzler MJ, et al. The spindle kinesin-like protein HsEg5 is an autoantigen in systemic lupus erythematosus. Arthritis Rheum 1996;39:1635-42.

    9. Szalat R, Ghillani-Dalbin P, Jallouli M, et al. Anti-NuMA1 and anti-NuMA2 (anti-HsEg5) antibodies: Clinical and immunological features: A propos of 40 new cases and review of the literature. Autoimmun Rev 2010;9:652-6.

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