►AC-28核型对任何疾病的阳性预测值均较低
►在常规血清学诊断中非常少见 (120)
►所识别的抗原包括 DCA、MCA1和 MCA5；这些自身抗体的特异性免疫检测试剂目前尚未商品化 (120-122)
| 简体中文 | ||
| 同义词 | 染色体表层蛋白，分裂细胞抗原，有丝分裂染色体自身抗原 | chromosome coat protein, dividing cell antigen, mitotic chromosome autoantigen (MCA) |
| 描述 | 细胞分裂前期和中期染色体可见点状染色，间期细胞无染色。 |
Punctate coloration of chromosomes in pro- and metaphase with no staining of interphase cells. |
| 抗原相关性 | 修饰的组蛋白H3，MCA-1 | modified histone H3, MCA-1 |
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► The AC-28 pattern has low positive predictive value for any disease
► Found very infrequently in a routine serology diagnostic setting (120)
► Antigens recognized include DCA, MCA1, and MCA5; specific immunoassays for these autoantibodies are currently not commercially available (120–122)
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一级信息参考文献First level information references
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120. Gitlits VM, Macaulay SL, Toh BH, et al. Novel human autoantibodies to phosphoepitopes on mitotic chromosomal autoantigens (MCAs). J Investig Med 2000;48:172–82.
121. Blaschek M, Muller S, Youinou P. Anti-"dividing cell antigen" autoantibody: a novel antinuclear antibody pattern related to histones in systemic lupus erythematosus. J Clin Immunol 1993;13:329–38.
122. Rayzman VM, Sentry JW. MCA1 detection of histone H3 serine 10 phosphorylation, a novel biomarker for determination of mitotic indices. Hum Antibodies 2006;15:71–80.
120. Gitlits VM, Macaulay SL, Toh BH, et al. Novel human autoantibodies to phosphoepitopes on mitotic chromosomal autoantigens (MCAs). J Investig Med 2000;48:172–82.
121. Blaschek M, Muller S, Youinou P. Anti-"dividing cell antigen" autoantibody: a novel antinuclear antibody pattern related to histones in systemic lupus erythematosus. J Clin Immunol 1993;13:329–38.
122. Rayzman VM, Sentry JW. MCA1 detection of histone H3 serine 10 phosphorylation, a novel biomarker for determination of mitotic indices. Hum Antibodies 2006;15:71–80.
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二级信息Second level information
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►抗DCA自身抗体曾在系统性红斑狼疮患者中被检出 (18)
►抗MCA1自身抗体曾在上皮细胞癌患者中被检出 (19)
►抗MCA5自身抗体曾在盘状红斑性狼疮、慢性淋巴细胞性白血病、 干燥综合征和风湿性多肌痛症患者中被检出 (20)
► Autoantibodies to DCA have been described in patients with SLE (18)
► Autoantibodies to MCA1 have been described in patients with carcinoma (19)
► Autoantibodies to MCA5 have been described in patients with discoid lupus erythematosus, chronic lymphocytic leukemia, SjS, and polymyalgia rheumatica (20)
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二级信息参考文献Second level information references
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18. Blaschek M, Muller S, Youinou P. Anti-"dividing cell antigen" autoantibody: a novel antinuclear antibody pattern related to histones in systemic lupus erythematosus. J Clin Immunol 1993;13:329-38.
19. Rayzman VM, Sentry JW. MCA1 detection of histone H3 serine 10 phosphorylation, a novel biomarker for determination of mitotic indices. Hum Antibodies 2006;15:71-80.
20. Gitlits VM, Macaulay SL, Toh BH, et al. Novel human autoantibodies to phosphoepitopes on mitotic chromosomal autoantigens (MCAs). J Investig Med 2000;48:172-82.
18. Blaschek M, Muller S, Youinou P. Anti-"dividing cell antigen" autoantibody: a novel antinuclear antibody pattern related to histones in systemic lupus erythematosus. J Clin Immunol 1993;13:329-38.
19. Rayzman VM, Sentry JW. MCA1 detection of histone H3 serine 10 phosphorylation, a novel biomarker for determination of mitotic indices. Hum Antibodies 2006;15:71-80.
20. Gitlits VM, Macaulay SL, Toh BH, et al. Novel human autoantibodies to phosphoepitopes on mitotic chromosomal autoantigens (MCAs). J Investig Med 2000;48:172-82.
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