►在系统性红斑狼疮、抗合成酶抗体综合征 (自身免疫性肌病的一种)、间质性肺病、多发性关节炎、雷诺现象和技工手的患者中有检出;这些特征可能以多种形式或单一形式出现,尤其是间质性肺病 (33, 86, 87)
►如果临床上疑似为系统性红斑狼疮,推荐后续检测抗核糖体P蛋白抗体 (包括P0、P1、P2和 C22多肽);这些抗原可能包含于常规的 ENA谱中
►在一些研究中,抗RibP抗体与神经精神性狼疮和儿童期发病的SLE合并自身免疫性溶血性贫血有关(86,88,89)
►如果疑似自身免疫性肌病,尤其是抗合成酶抗体综合征,推荐进行针对抗tRNA合成酶抗体的后续检测;该抗原包含于疾病特异性免疫试剂 (即,肌炎谱*)中 (26, 33)
►如果疑似自身免疫性肌病,尤其是坏死性肌病,推荐进行针对抗SRP抗体的后续检测;该抗原包含于疾病特异性免疫试剂(即,肌炎谱*)中 (26)
注:AC-19和AC-20之间的细微区别可能取决于HEp-2细胞底物和/或抗体浓度;在HEp-2细胞的间接免疫荧光筛查中可能检测不到针对RibP和tRNA合成酶的抗体。
*肌炎谱、系统性硬化症谱和自身免疫性肝病谱(扩展版)可能仅限于专业临床实验室应用。
► Found in patients with SLE and the anti-synthetase syndrome (a subset of AIM), interstitial lung disease, polyarthritis, Raynaud’s phenomenon, and mechanic’s hands; these features may occur in various combinations or as an isolated manifestation, especially interstitial lung disease (33, 86, 87)
► If SLE is clinically suspected, follow-up tests for antibodies to ribosomal P phosphoproteins (P0, P1, P2, C22 RibP peptide) are recommended; these antigens may be included in the routine ENA profile
► Anti-RibP antibodies have been associated in some studies with neuropsychiatric lupus, and in childhood-onset SLE with autoimmune hemolytic anemia (86, 88, 89)
► If AIM, in particular the anti-synthetase syndrome, is suspected, it is recommended to perform follow-up tests for antibodies to tRNA synthetases; antigens are included in disease specific immunoassays (i.e., inflammatory myopathy profile*) (26, 33)
► If AIM, in particular necrotizing myopathy, is suspected, it is recommended to perform follow-up tests for anti-SRP antibodies; the antigen is included in disease specific immunoassays (i.e., inflammatory myopathy profile*) (26)
Notes: The fine distinction between AC-19 and -20 may depend on HEp-2 substrates and/or antibody concentration; antibodies to both RibP as well as tRNA synthetases may be undetected in HEp-2 IIFA-screening.
*Availability of the inflammatory myopathy profile, the SSc profile and the (extended) liver profile may be limited to specialty clinical laboratories.