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AC-1-均质型

同义词 弥散 Diffuse
描述

细胞核呈现均匀荧光，根据细胞基质的不同，部分核仁有荧光。分裂期细胞（中期，后期和末期）染色质浓缩成为染色体呈均匀、透明的荧光，且亮度更强。

 Homogeneous and regular fluorescence across all nucleoplasm. The nucleoli maybe stained or not stained depending on cell substrate. Mitotic cells (metaphase, anaphase, and telophase) have the chromatin mass intensely stained in a homogeneous hyaline fashion.
抗原相关性 双链DNA,核小体，组蛋白 dsDNA, nucleosomes, histones

  • 临床相关性

    一级信息

    关于临床相关性和缩写列表

    Clinical Relevance

    First level information

    About Clinical Relevance & List of Abbreviations

  • ►见于系统性红斑狼疮、慢性自身免疫性肝炎或幼年特发性关节炎的患者中

    ►如果临床上怀疑系统性红斑狼疮，建议进一步检测dsDNA抗体或dsDNA/组蛋白复合物（核小体/染色质）抗体；系统性红斑狼疮的分类标准中包括抗dsDNA抗体（15，16）

    ►如果怀疑是慢性自身免疫性肝炎或幼年特发性关节炎，则不建议进行进一步检测，因为目前已知的有关AC-1核型的靶抗原尚未完全明确（17）

    注：虽然拓扑异构酶I（以前的Scl-70）的自身抗体可能被报告为核均质的，但它们通常显示出一种复合的AC-29 的HEp-2 荧光核型；因此，临床怀疑系统性硬化症的患者可能需要对该抗体进行进一步检测（14，18）

    尽管AC-1是慢性自身免疫性肝炎中最常见的核型，但其他HEp-2 荧光核型也可能出现，但对于这些核型的靶抗原也尚未完全明确（19）


    ▶Found in patients with SLE, chronic autoimmune hepatitis or juvenile idiopathic arthritis
    ▶If SLE is clinically suspected, it is recommended to perform a follow-up test for anti-dsDNA antibodies, alone or in combination with dsDNA/histone complexes (nucleosomes/chromatin); anti-dsDNA antibodies are included in the classification criteria for SLE (15, 16)

    ▶If chronic autoimmune hepatitis or juvenile idiopathic arthritis is suspected, follow-up testing is not recommended because the respective autoantigens revealing the AC-1 pattern are not completely defined (17)

    Notes: Although autoantibodies to Topoisomerase I (formerly Scl-70) may be reported as nuclear homogeneous, they typically reveal a composite AC-29 HEp-2 IIFA pattern; as such, clinical suspicion of SSc may warrant follow-up testing for reactivity to this antigen (14, 18)
  • 一级信息参考文献
    First level information references
  • 14.Andrade LEC, Klotz W, Herold M, et al. International consensus on antinuclear antibody patterns: definition of the ac-29 pattern associated with antibodies to DNA topoisomerase I. Clin Chem Lab Med 2018;56:1783–8.
    15.Conrad K, Schössler W, Hiepe F. Autoantibodies in systemic autoimmune diseases: a diagnostic reference. 2. 3th edn. Autoantigens autoantibodies autoimmunity, 2015.
    16.Petri M, Orbai AM, Alarcón GS, et al. Derivation and validation of the systemic lupus international collaborating clinics classification criteria for systemic lupus erythematosus. Arthritis Rheum 2012;64:2677–86.
    17.Conrad K, Schössler W, Hiepe F. Autoantibodies in organ specific autoimmune diseases. a diagnostic reference. 8. 2th edn. Autoantigens autoantibodies autoimmunity, 2017.
    18.Dellavance A, Gallindo C, Soares MG, et al. Redefining the Scl-70 indirect immunofluorescence pattern: autoantibodies to DNA topoisomerase I yield a specific compound immunofluorescence pattern. Rheumatology 2009;48:632–7.
    19.European Association for the Study of the Liver. EASL clinical practice guidelines: autoimmune hepatitis. J Hepatol 2015;63:971–1004.


    14.Andrade LEC, Klotz W, Herold M, et al. International consensus on antinuclear antibody patterns: definition of the ac-29 pattern associated with antibodies to DNA topoisomerase I. Clin Chem Lab Med 2018;56:1783–8.
    15.Conrad K, Schössler W, Hiepe F. Autoantibodies in systemic autoimmune diseases: a diagnostic reference. 2. 3th edn. Autoantigens autoantibodies autoimmunity, 2015.
    16.Petri M, Orbai AM, Alarcón GS, et al. Derivation and validation of the systemic lupus international collaborating clinics classification criteria for systemic lupus erythematosus. Arthritis Rheum 2012;64:2677–86.
    17.Conrad K, Schössler W, Hiepe F. Autoantibodies in organ specific autoimmune diseases. a diagnostic reference. 8. 2th edn. Autoantigens autoantibodies autoimmunity, 2017.
    18.Dellavance A, Gallindo C, Soares MG, et al. Redefining the Scl-70 indirect immunofluorescence pattern: autoantibodies to DNA topoisomerase I yield a specific compound immunofluorescence pattern. Rheumatology 2009;48:632–7.
    19.European Association for the Study of the Liver. EASL clinical practice guidelines: autoimmune hepatitis. J Hepatol 2015;63:971–1004.
  • 二级信息
    Second level information

  • 无

    None
  • 二级信息参考文献
    Second level information references

  • 无

    None

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