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AC-10-核仁颗粒型

同义词 核仁斑点状
描述

间期细胞核仁产生密集、清晰的颗粒状荧光,分裂中期细胞胞浆内最多可见5对明亮的核仁组成体(NOR),分裂期细胞胞浆可呈现微弱荧光。例如抗NOR-90抗体,抗RNA聚合酶I抗体。

抗原相关性 RNA聚合酶I,hUBF/NOR-90
  • 临床相关性

    一级信息

    关于临床相关性和缩写列表

    Clinical Relevance

    First level information

    About Clinical Relevance & List of Abbreviations
  • ►AC-10核型可以在多种情况下看到,包括系统性硬化症、雷诺现象、干燥综合征和癌症(52-56)

    ►如果在上述情况的患者血清中发现AC-10核型,则随后应考虑进行抗NOR90 (hUBF)抗体检测;该抗原包含在疾病特异性免疫检测中(例如,系统性硬化症抗体谱)(54-55)

    ►虽然AC-10与抗RNApol I抗体相关,但这些抗体几乎总是与抗RNApol III抗体共存,显示AC-5核型;因此,如果临床怀疑有系统性硬化症,建议对抗RNApol III抗体进行随访检测(参见AC-5);针对抗RNApol I抗体的特异性免疫测定还没有商业试剂盒(52,53,57)

    *实用的炎症性肌病谱、系统性硬化症谱和自免肝疾病谱(扩展版)检测可能仅限于专业的临床实验室。


  • 一级信息参考文献
    First level information references
  • 52. Reimer G, Rose KM, Scheer U, et al. Autoantibody to RNA polymerase I in scleroderma sera. J Clin Invest 1987;79:65–72.

    53. Kuwana M, Kaburaki J, Mimori T, et al. Autoantibody reactive with three classes of RNA polymerases in sera from patients with systemic sclerosis. J Clin Invest 1993;91:1399–404.

    54. Fritzler MJ, von Muhlen CA, Toffoli SM, et al. Autoantibodies to the nucleolar organizer antigen NOR-90 in children with systemic rheumatic diseases. J Rheumatol 1995;22:521–4.

    55. Fujii T, Mimori T, Akizuki M. Detection of autoantibodies to nucleolar transcription factor nor 90/hUBF in sera of patients with rheumatic diseases, by recombinant autoantigen-based assays. Arthritis Rheum 1996;39:1313–8.

    56. Imai H, Ochs RL, Kiyosawa K, et al. Nucleolar antigens and autoantibodies in hepatocellular carcinoma and other malignancies. Am J Pathol 1992;140:859–70.

    57. Yamasaki Y, Honkanen-Scott M, Hernandez L, et al. Nucleolar staining cannot be used as a screening test for the scleroderma marker anti-RNA polymerase I/III antibodies. Arthritis Rheum 2006;54:3051–6.


  • 二级信息
    Second level information

  • 二级信息参考文献
    Second level information references

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