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AC-11-光滑核膜型

同义词 核边缘，核膜，膜状 nuclear rim, nuclear membrane, membranous
描述

细胞核呈现均匀荧光，核周增强；分裂中期和后期细胞的染色体阴性；临近细胞相触部位荧光增强。例如抗板层素B抗体。

 Homogeneous staining of the nucleus with greater intensity at its outer rim and no staining at the metaphase and anaphase chromatin plates. There is a peculiar accentuation of the fluorescence at the points where adjacent cells touch each other. e.g. anti-lamin B.
抗原相关性 板层素A，B，C，或板层素相关蛋白 lamins A,B,C, or lamin-associated proteins

  • 临床相关性

    一级信息

    关于临床相关性和缩写列表

    Clinical Relevance

    First level information

    About Clinical Relevance & List of Abbreviations

  • ►AC-11核型很少在常规的自身抗体检测中发现，在自身免疫性细胞减少症、自身免疫性肝病、带状硬皮病、抗磷脂综合征和系统性自身免疫性风湿疾病中都有描述；目前关于临床相关性的信息主要基于病例报告和小群体研究(58-60)

    ►被识别的抗原包括lamins (A、B、C)和LAP-2;目前还没有针对这些自身抗体的特异性免疫检测商品化试剂盒（58-60）

    ► The AC-11 pattern is infrequently found in routine autoantibody testing and has been described in autoimmune-cytopenias, autoimmune liver diseases, linear scleroderma, APS, and SARD; current information on clinical associations is based mainly on case reports and small cohorts (58–60)

    ► Antigens recognized include lamins (A, B, C) and LAP-2; specific immunoassays for these autoantibodies are currently not commercially available (58–60)

  • 一级信息参考文献
    First level information references

  • 58. Coppo P, Clauvel JP, Bengoufa D, et al. Autoimmune cytopenias associated with autoantibodies to nuclear envelope polypeptides. Am J Hematol 2004;77:241–9.

    59. Konstantinov K, Foisner R, Byrd D, et al. Integral membrane proteins associated with the nuclear lamina are novel autoimmune antigens of the nuclear envelope. Clin Immunol Immunopathol 1995;74:89–99.

    60. Reeves WH, Chaudhary N, Salerno A, et al. Lamin B autoantibodies in sera of certain patients with systemic lupus erythematosus. J Exp Med 1987;165:750–62.


    58. Coppo P, Clauvel JP, Bengoufa D, et al. Autoimmune cytopenias associated with autoantibodies to nuclear envelope polypeptides. Am J Hematol 2004;77:241–9.

    59. Konstantinov K, Foisner R, Byrd D, et al. Integral membrane proteins associated with the nuclear lamina are novel autoimmune antigens of the nuclear envelope. Clin Immunol Immunopathol 1995;74:89–99.

    60. Reeves WH, Chaudhary N, Salerno A, et al. Lamin B autoantibodies in sera of certain patients with systemic lupus erythematosus. J Exp Med 1987;165:750–6

  • 二级信息
    Second level information

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  • 二级信息参考文献
    Second level information references

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