►AC-11核型很少在常规的自身抗体检测中发现,在自身免疫性细胞减少症、自身免疫性肝病、带状硬皮病、抗磷脂综合征和系统性自身免疫性风湿疾病中都有描述;目前关于临床相关性的信息主要基于病例报告和小群体研究(58-60)
►被识别的抗原包括lamins (A、B、C)和LAP-2;目前还没有针对这些自身抗体的特异性免疫检测商品化试剂盒(58-60)
简体中文 | English | |
同义词 | 核边缘,核膜,膜状 | nuclear rim, nuclear membrane, membranous |
描述 | 细胞核呈现均匀荧光,核周增强;分裂中期和后期细胞的染色体阴性;临近细胞相触部位荧光增强。例如抗板层素B抗体。 |
Homogeneous staining of the nucleus with greater intensity at its outer rim and no staining at the metaphase and anaphase chromatin plates. There is a peculiar accentuation of the fluorescence at the points where adjacent cells touch each other. e.g. anti-lamin B. |
抗原相关性 | 板层素A,B,C,或板层素相关蛋白 | lamins A,B,C, or lamin-associated proteins |
►AC-11核型很少在常规的自身抗体检测中发现,在自身免疫性细胞减少症、自身免疫性肝病、带状硬皮病、抗磷脂综合征和系统性自身免疫性风湿疾病中都有描述;目前关于临床相关性的信息主要基于病例报告和小群体研究(58-60)
►被识别的抗原包括lamins (A、B、C)和LAP-2;目前还没有针对这些自身抗体的特异性免疫检测商品化试剂盒(58-60)
► The AC-11 pattern is infrequently found in routine autoantibody testing and has been described in autoimmune-cytopenias, autoimmune liver diseases, linear scleroderma, APS, and SARD; current information on clinical associations is based mainly on case reports and small cohorts (58–60)
► Antigens recognized include lamins (A, B, C) and LAP-2; specific immunoassays for these autoantibodies are currently not commercially available (58–60)
58. Coppo P, Clauvel JP, Bengoufa D, et al. Autoimmune cytopenias associated with autoantibodies to nuclear envelope polypeptides. Am J Hematol 2004;77:241–9.
59. Konstantinov K, Foisner R, Byrd D, et al. Integral membrane proteins associated with the nuclear lamina are novel autoimmune antigens of the nuclear envelope. Clin Immunol Immunopathol 1995;74:89–99.
60. Reeves WH, Chaudhary N, Salerno A, et al. Lamin B autoantibodies in sera of certain patients with systemic lupus erythematosus. J Exp Med 1987;165:750–62.
58. Coppo P, Clauvel JP, Bengoufa D, et al. Autoimmune cytopenias associated with autoantibodies to nuclear envelope polypeptides. Am J Hematol 2004;77:241–9.
59. Konstantinov K, Foisner R, Byrd D, et al. Integral membrane proteins associated with the nuclear lamina are novel autoimmune antigens of the nuclear envelope. Clin Immunol Immunopathol 1995;74:89–99.
60. Reeves WH, Chaudhary N, Salerno A, et al. Lamin B autoantibodies in sera of certain patients with systemic lupus erythematosus. J Exp Med 1987;165:750–6
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细胞核周阳性但中心阴性?有时可观察到细胞核的外周有类似阳性的染色,而细胞核中心是阴性的,这种现象的原因是什么?
日期:2019年04月05日