简体中文

AC-27-细胞间桥型

同义词 茎体, 中间体 chromosome coat protein, dividing cell antigen, mitotic chromosome autoantigen (MCA)
描述

在有丝分裂后期，即将分离的两个细胞中间的细胞间桥有荧光染色。

 Punctate coloration of chromosomes in pro- and metaphase with no staining of interphase cells.
抗原相关性 无 modified histone H3, MCA-1

  • 临床相关性

    一级信息

    关于临床相关性和缩写列表

    Clinical Relevance

    First level information

    About Clinical Relevance & List of Abbreviations

  • ► AC-27核型对任何疾病的阳性预测值均较低(116)

    ►在常规血清学诊断中非常少见(117)

    ►所识别的抗原包括 CENP-E、CENP-F、TD60、MSA36、KIF-14、MKLP-1、MPP1/KIF20B和 INCENP；这些自身抗体的特异性免疫检测试剂目前尚未商品化 (116, 118, 119)



    ► The AC-28 pattern has low positive predictive value for any disease

    ► Found very infrequently in a routine serology diagnostic setting (120)

    ► Antigens recognized include DCA, MCA1, and MCA5; specific immunoassays for these autoantibodies are currently not commercially available (120–122)

  • 二级信息
    Second level information

  • ►在系统性硬化症、雷诺现象和恶性肿瘤的患者中偶有检出(10-12)

    ►对 CENP-E、CENP-F、TD60、MSA36、KIF-14和MKLP-1的自身抗体在系统性硬化症 (局限型和弥漫型)、系统性红斑狼疮和恶性肿瘤患者中均有报道 (13,14)

    ►INCENP自身抗体曾在一例假性斑秃-毛周角化综合征患者中被检出 (15)

    ►MPP1/KIF20B (M期磷蛋白1) 自身抗体曾在特发性共济失调、其他神经综合征和阵发性夜间血红蛋白尿的患者中被检出 (16,17)

    注：大多数报道都描述了自身抗体直接与特异性抗原结合(即抗原特异性免疫分析)，实际并未显示与AC-27模式相关性；这些自身抗体的特异性免疫检测试剂目前尚未商品化。


    ► Autoantibodies to DCA have been described in patients with SLE (18)

    ► Autoantibodies to MCA1 have been described in patients with carcinoma (19)

    ► Autoantibodies to MCA5 have been described in patients with discoid lupus erythematosus, chronic lymphocytic leukemia, SjS, and polymyalgia rheumatica (20)

  • 参考文献

  • 10. Fritzler MJ, Ayer LM, Gohill J, et al. An antigen in metaphase chromatin and the midbody of mammalian cells binds to scleroderma sera. J Rheumatol 1987;14:291-4.

    11. Tausche AK, Conrad K, Seidel W, et al. Anti-midbody antibodies as a possible predictive factor for a special limited or abortive form of systemic sclerosis? Ann Rheum Dis 2005;64:1237-8.

    12. Vermeersch P, Bossuyt X. Prevalence and clinical significance of rare antinuclear antibody patterns. Autoimmun Rev 2013;12:998-1003.

    13. Rattner JB, Mack GJ, Fritzler MJ. Autoantibodies to components of the mitotic apparatus. Mol Biol Rep 1998;25:143-55.

    14. Humbel RL. Autoantibodies to mitotic cells. in Dresden Autoantibody Symposium (eds. Conrad, K., et al.) 327-39 (Pabst Science, Dresden, Germany, 2013).

    15. Rodriguez-Bayona B, Ruchaud S, Rodriguez C, et al. Autoantibodies against the chromosomal passenger protein INCENP found in a patient with Graham Little-Piccardi-Lassueur syndrome. J Autoimmune Dis 2007;4:1.

    16. Fritzler MJ, Kerfoot SM, Feasby TE, et al. Autoantibodies from patients with idiopathic ataxia bind to M-phase phosphoprotein 1 (MPP-1). J Invest Med 2000;48:28-39.

    17. Alahmad A, Preuss KD, Schenk J, et al. Desmoplakin and KIF20B as target antigens in patients with paroxysmal nocturnal haemoglobinuria. Br J Haematol 2010;151:273-80.


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