ICAP
AC-28 - 染色体型
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同义词 染色体表层蛋白,分裂细胞抗原,有丝分裂染色体自身抗原 chromosome coat protein, dividing cell antigen, mitotic chromosome autoantigen (MCA)
描述

细胞分裂前期和中期染色体可见点状染色,间期细胞无染色。

Punctate coloration of chromosomes in pro- and metaphase with no staining of interphase cells.

抗原相关性 修饰的组蛋白H3,MCA-1 modified histone H3, MCA-1
临床相关性
一级信息
关于临床相关性和缩写列表
Clinical Relevance
First level information
About Clinical Relevance & List of Abbreviations

►AC-28核型对任何疾病的阳性预测值均较低

►在常规血清学诊断中非常少见 (120)

►所识别的抗原包括 DCA、MCA1和 MCA5;这些自身抗体的特异性免疫检测试剂目前尚未商品化 (120-122)

► The AC-28 pattern has low positive predictive value for any disease

► Found very infrequently in a routine serology diagnostic setting (120)

► Antigens recognized include DCA, MCA1, and MCA5; specific immunoassays for these autoantibodies are currently not commercially available (120–122)


一级信息参考文献 First level information references

120. Gitlits VM, Macaulay SL, Toh BH, et al. Novel human autoantibodies to phosphoepitopes on mitotic chromosomal autoantigens (MCAs). J Investig Med 2000;48:172–82.

121. Blaschek M, Muller S, Youinou P. Anti-"dividing cell antigen" autoantibody: a novel antinuclear antibody pattern related to histones in systemic lupus erythematosus. J Clin Immunol 1993;13:329–38.

122. Rayzman VM, Sentry JW. MCA1 detection of histone H3 serine 10 phosphorylation, a novel biomarker for determination of mitotic indices. Hum Antibodies 2006;15:71–80.


120. Gitlits VM, Macaulay SL, Toh BH, et al. Novel human autoantibodies to phosphoepitopes on mitotic chromosomal autoantigens (MCAs). J Investig Med 2000;48:172–82.

121. Blaschek M, Muller S, Youinou P. Anti-"dividing cell antigen" autoantibody: a novel antinuclear antibody pattern related to histones in systemic lupus erythematosus. J Clin Immunol 1993;13:329–38.

122. Rayzman VM, Sentry JW. MCA1 detection of histone H3 serine 10 phosphorylation, a novel biomarker for determination of mitotic indices. Hum Antibodies 2006;15:71–80.


二级信息 Second level information

►抗DCA自身抗体曾在系统性红斑狼疮患者中被检出 (18)

►抗MCA1自身抗体曾在上皮细胞癌患者中被检出 (19)

►抗MCA5自身抗体曾在盘状红斑性狼疮、慢性淋巴细胞性白血病、 干燥综合征和风湿性多肌痛症患者中被检出 (20)


► Autoantibodies to DCA have been described in patients with SLE (18)

► Autoantibodies to MCA1 have been described in patients with carcinoma (19)

► Autoantibodies to MCA5 have been described in patients with discoid lupus erythematosus, chronic lymphocytic leukemia, SjS, and polymyalgia rheumatica (20)


二级信息参考文献 Second level information references

18. Blaschek M, Muller S, Youinou P. Anti-"dividing cell antigen" autoantibody: a novel antinuclear antibody pattern related to histones in systemic lupus erythematosus. J Clin Immunol 1993;13:329-38.

19. Rayzman VM, Sentry JW. MCA1 detection of histone H3 serine 10 phosphorylation, a novel biomarker for determination of mitotic indices. Hum Antibodies 2006;15:71-80.

20. Gitlits VM, Macaulay SL, Toh BH, et al. Novel human autoantibodies to phosphoepitopes on mitotic chromosomal autoantigens (MCAs). J Investig Med 2000;48:172-82.


18. Blaschek M, Muller S, Youinou P. Anti-"dividing cell antigen" autoantibody: a novel antinuclear antibody pattern related to histones in systemic lupus erythematosus. J Clin Immunol 1993;13:329-38.

19. Rayzman VM, Sentry JW. MCA1 detection of histone H3 serine 10 phosphorylation, a novel biomarker for determination of mitotic indices. Hum Antibodies 2006;15:71-80.

20. Gitlits VM, Macaulay SL, Toh BH, et al. Novel human autoantibodies to phosphoepitopes on mitotic chromosomal autoantigens (MCAs). J Investig Med 2000;48:172-82.


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Online since 19 May 2015