简体中文

AC-31-多散点型

同义词 AC-4a, 核细颗粒型 AC-4a, nuclear fine speckled
描述 在核质中可见无数细小而离散的散点颗粒，呈现出该模型特征性的“多散点”核型。核仁不被染色。在有丝分裂细胞（中期、后期和末期），染色体染色阴性，而其周围的胞浆则呈现明显的染色 Fine tiny discrete speckles are distributed throughout the nucleoplasm representing the characteristic myriad discrete speckled nuclear pattern. The nucleoli are not stained. In mitotic cells (metaphase, anaphase, and telophase) the chromatin mass is not stained which is in contrast to the surrounding cytoplasm.
抗原相关性 AC-31核型与抗TROVE2/Ro60抗体（曾称为SS-A/Ro60（1）高度相关（2-4）。相比之下，单纯的细颗粒型（AC-4）与抗TROVE2/Ro60抗体的的相关性要低得多。当抗TROVE2/Ro60阳性样本中存在其他抗核抗体时，往往会掩盖AC-31模型的典型特征，因此这类阳性样本可能不会呈现预期的AC-31模型（4）。 The AC-31 pattern is strongly associated with anti-TROVE2/Ro60 (formerly known as SS-A/Ro60 [1]) antibodies[2-4]. In contrast, the plain fine speckled pattern (AC-4) is much less frequently associated with anti-TROVE2/Ro60. The coexistence of additional antinuclear antibodies in anti-TROVE2/Ro60 positive samples frequently obscures the unambiguous features of the AC-31 pattern; therefore, such anti-TROVE2/Ro60 positive samples may not show the expected AC-31 pattern [4].

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  • ▶由于AC-31核型与抗TROVE2/Ro60抗体具有强烈相关性，该核型常见于系统性红斑狼疮(SLE)和干燥综合征(SjD)患者。与AC-4核细颗粒型相比(该核型是无症状人群及非自身免疫性疾病患者中最常见的荧光核型之一)，但AC-31核型在健康个体中并不常见。

    Because of the strong association with anti-TROVE2/Ro60 antibodies, the AC-31 pattern is frequently seen in patients with systemic lupus erythematosus (SLE) and Sjögren’s disease (SjD). It is not commonly observed in healthy individuals, as opposed to the AC-4 plain fine speckled nuclear pattern that is one of the most frequent HEp-2 IFA patterns in asymptomatic individuals and patients with no systemic autoimmune disease.

  • 一级信息参考文献
    First level information references

  • 1.Ben-Chetrit E, Fritzler MJ, Andrade LEC, Chan EKL, Choi M, et al. Revised terminology for SS-A/Ro antigens by Delphi consensus. in preparation. 2025.

    2.Andrade LEC, Klotz W, Herold M, Musset L, Damoiseaux J, Infantino M, Carballo OG, Choi M, et al. Reflecting on a decade of the international consensus on ANA patterns (ICAP): Accomplishments and challenges from the perspective of the 7th ICAP workshop. Autoimmun Rev. 2024;23:103608.

    3.Dellavance A, Alvarenga RR, Rodrigues SH, Barbosa SH, Camilo AC, Shiguedomi HS, Rodrigues SS, Silva CG, et al. Autoantibodies to 60kDa SS-A/Ro yield a specific nuclear myriad discrete fine speckled immunofluorescence pattern. J Immunol Methods. 2013;390:35-40.

    4.Rober N, Dellavance A, Ingenito F, Reimer ML, Carballo OG, Conrad K, Chan EKL, Andrade LEC. Strong Association of the Myriad Discrete Speckled Nuclear Pattern With Anti-SS-A/Ro60 Antibodies: Consensus Experience of Four International Expert Centers. Front Immunol. 2021;12:730102.

    1.Ben-Chetrit E, Fritzler MJ, Andrade LEC, Chan EKL, Choi M, et al.Revised terminology for SS-A/Ro antigens by Delphi consensus. in preparation.2025.

    2.Andrade LEC, Klotz W, Herold M, Musset L, Damoiseaux J, Infantino M, Carballo OG, Choi M, et al.Reflecting on a decade of the international consensus on ANA patterns (ICAP): Accomplishments and challenges from the perspective of the 7th ICAP workshop. Autoimmun Rev. 2024;23:103608.

    3.Dellavance A, Alvarenga RR, Rodrigues SH, Barbosa SH, Camilo AC, Shiguedomi HS, Rodrigues SS, Silva CG, et al. Autoantibodies to 60kDa SS-A/Ro yield a specific nuclear myriad discrete fine speckled immunofluorescence pattern. J Immunol Methods. 2013;390:35-40.

    4.Rober N, Dellavance A, Ingenito F, Reimer ML, Carballo OG, Conrad K, Chan EKL, Andrade LEC. Strong Association of the Myriad Discrete Speckled Nuclear Pattern With Anti-SS-A/Ro60 Antibodies: Consensus Experience of Four International Expert Centers. Front Immunol. 2021;12:730102.

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