简体中文

AC-30-细颗粒伴有丝分裂板型

同义词 假性-DFS（1）; 细颗粒伴有丝分裂板型 Pseudo-DFS [1]; Nuclear Speckled with Positive Metaphases; Nuclear Homogeneous Speckled; Nuclear Homo/Speckled.
描述 斑点型荧光核型均匀分布于整个间期细胞核，在斑点的大小、亮度和分布上均表现出均一性。在中期极（染色体板）上也可观察到类似的斑点模型。但是，若同时存在核斑点型荧光而且中期极带有均质（透明）纹理，则应归类为混合型核荧光模型（混合型），而非AC-30（2, 3）。 The speckled staining pattern is uniformly distributed throughout the interphase nucleus, exhibiting homogeneity in speckle size, brightness, and distribution. A similar speckled pattern is observed in the metaphase plate. Importantly, a nuclear speckled pattern with the metaphase plate with a homogeneous (hyaline) texture should be classified as a mixed nuclear pattern and not as AC-30 [2, 3].
抗原相关性 AC-30样本通常不伴有已知的自身抗体。但是，AC-30模型也可能由多种临床相关自身抗体共同存在而产生，特别是靶抗原为dsDNA、核小体、Sm、U1-RNP、Scl-70/topo-I、SS-A/Ro60（先前称为SS-A/Ro60 （4）和/或SS-B/La的抗体。两种或多种上述抗体的共存可能会干扰其各自特征性模型的表达，从而导致AC-30模型的出现。因此，AC-30可被视为混合模型的一种特定情况。除此之外，部分AC-30样本含有抗DFS70抗体与其他抗核抗体的组合，这种组合可能掩盖典型的抗DFS70相关AC-2模型。 AC-30 samples frequently do not exhibit a known autoantibody. However, the AC-30 pattern can also arise from the concurrent presence of multiple clinically relevant autoantibodies, particularly those targeting dsDNA, nucleosomes, Sm, U1-RNP, Scl-70/topo-I, SS-A/Ro60 (formerly known as SS-A/Ro60 [4]), and/or SS-B/La. The coexistence of two or more of these antibodies may interfere with the expression of their individual characteristic patterns, resulting in the AC-30 pattern. In this context, the AC-30 can be considered a specific case of mixed pattern. Additionally, some AC-30 samples contain anti-DFS70 antibodies in combination with other antinuclear antibodies, which can mask the typical anti-DFS70-associated AC-2 pattern.

  • 临床相关性

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    Clinical Relevance

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  • AC-30荧光模型常见于无明显自身免疫性疾病的个体。但是，由于该模型可能反映多种抗核抗体的联合反应性，因此偶尔也可见于患有系统性自身免疫性风湿病的患者，特别是在存在多种抗核抗体的情况下（2, 5）。

    The AC-30 pattern is commonly observed in individuals without any apparent autoimmune disease. However, since it may reflect the combined reactivity of several antinuclear antibodies, the AC-30 pattern can occasionally be seen in patients with systemic autoimmune rheumatic diseases, especially in cases with multiple antinuclear antibodies [2, 5].

  • 一级信息参考文献
    First level information references

  • 1.Infantino M, Bizzaro N, Grossi V, Manfredi M. The long-awaited 'pseudo-DFS pattern'. Expert Rev Clin Immunol. 2019;15:445.

    2.Andrade LEC, Klotz W, Herold M, Musset L, Damoiseaux J, Infantino M, Carballo OG, Choi M, et al. Reflecting on a decade of the international consensus on ANA patterns (ICAP): Accomplishments and challenges from the perspective of the 7th ICAP workshop. Autoimmun Rev. 2024;23:103608.

    3.de Melo Cruvinel W, Ferreira GG, de Souza LL, da Costa Veloso Neto W, Gomes CM, Francescantonio PLC, Andrade LEC. The spectrum of nuclear patterns with stained metaphase chromosome plate: morphology nuances, immunological associations, and clinical relevance. Clin Chem Lab Med. 2025.

    4.Ben-Chetrit E, Fritzler MJ, Andrade LEC, Chan EKL, Choi M, et al. Revised terminology for SS-A/Ro antigens by Delphi consensus. in preparation. 2025.

    5.Durmus MA, Komec S. Frequency of the AC-2 pattern's new variant (AC-30) and detection of different immunological relationships. Clin Immunol. 2025;278:110536.

    1.Infantino M, Bizzaro N, Grossi V, Manfredi M. The long-awaited 'pseudo-DFS pattern'.Expert Rev Clin Immunol. 2019;15:445.

    2.Andrade LEC, Klotz W, Herold M, Musset L, Damoiseaux J, Infantino M, Carballo OG, Choi M, et al.Reflecting on a decade of the international consensus on ANA patterns (ICAP): Accomplishments and challenges from the perspective of the 7th ICAP workshop.Autoimmun Rev. 2024;23:103608.

    3.de Melo Cruvinel W, Ferreira GG, de Souza LL, da Costa Veloso Neto W, Gomes CM, Francescantonio PLC, Andrade LEC.The spectrum of nuclear patterns with stained metaphase chromosome plate: morphology nuances, immunological associations, and clinical relevance.Clin Chem Lab Med. 2025.

    4.Ben-Chetrit E, Fritzler MJ, Andrade LEC, Chan EKL, Choi M, et al.Revised terminology for SS-A/Ro antigens by Delphi consensus. in preparation. 2025.

    5.Durmus MA, Komec S. Frequency of the AC-2 pattern's new variant (AC-30) and detection of different immunological relationships. Clin Immunol. 2025;278:110536.

  • 二级信息
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  • 二级信息参考文献
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