▶初步研究报告未显示该模型对任何疾病具有阳性预测价值。其与恶性肿瘤的潜在关联性目前仍在研究中。
| 简体中文 | ||
| 同义词 | 假性PCNA I型 （1） | Pseudo-PCNA I [1] |
| 描述 | 核细颗粒样染色在部分间期细胞中呈细胞周期依赖性荧光染色。所有阳性细胞中均呈现纹理均匀的颗粒样荧光，故该模型不属于多形性模型。初步研究表明，阳性染色细胞处于细胞周期的S期和G2期，而处于G1期的细胞则不显色。分裂中期细胞染色体板阴性或仅见极微弱的外周细颗粒染色。所有细胞中均未观察到核仁染色或核粗颗粒染色。 | Fine speckled nuclear staining that is cell-cycle dependent in a portion of interphase cells. The texture of the speckled pattern is uniform in all cells; therefore, this is not classified as a pleomorphic pattern. Preliminary studies indicate that stained cells are in the S and G2 phases of the cell cycle, but those in the G1 phase, are not stained. The metaphase plate is either not stained or has very weak peripheral fine speckled staining. There is no staining of nucleoli or coarse speckled nuclear staining in any cell. |
| 抗原相关性 | 最初通过表达克隆技术鉴定的SG2NA蛋白，被证实定位于组织培养细胞的S期和G2期细胞核（2, 3）。目前该SG2NA蛋白现称为striatin-3异构体2，这是striatin-3异构体1经过选择性剪接缺失第8和第9外显子后形成的变体。但是，人来源抗striatin血清在HEp-2细胞间接免疫荧光检测中并未显示任何一种具有一致性特征的荧光模型（4）。仍需进一步研究。 | The initial identification of the SG2NA protein based on expression cloning was shown localized to S and G2 phase nuclei of tissue culture cells [2, 3]. Currently this SG2NA protein is now known as striatin-3 isoform 2, an alternatively spliced form missing exon 8 and 9 in the full-length striatin-3 isoform 1. Human anti-striatin sera, however, do not show any consistent staining in HEp-2 IFA [4]. Further research is needed. |
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▶Preliminary reports do not indicate a positive predictive value for any disease. A possible relationship to malignancy is under investigation.
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一级信息参考文献First level information references
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1.Guffroy A, Dima A, Nespola B, Poindron V, Sibilia J, Herbrecht R, De Seze J, Habersetzer F, et al.Anti-pseudo-PCNA type 1 (anti-SG2NA) pattern: Track down Cancer, not SLE. Joint Bone Spine. 2016;83:330-4.
2.Muro Y, Chan EKL, Landberg G, Tan EM. A cell-cycle nuclear autoantigen containing WD-40 motifs expressed mainly in S and G2 phase cells. Biochem Biophys Res Commun. 1995;207:1029-37.
3.Landberg G, Tan EM. Characterization of a DNA-binding nuclear autoantigen mainly associated with S phase and G2 cells.Exp Cell Res. 1994;212:255-61.
4.Fritzler MJ, Muro Y, Klotz W, Herold M, Andrade LEC, Grecco M, Satoh M, Choi M, et al.Striatin is a human autoantigen but it is not associated with the S and G2 phase nuclear antigen (SG2NA) staining pattern. 2025;in preparation.
1.Guffroy A, Dima A, Nespola B, Poindron V, Sibilia J, Herbrecht R, De Seze J, Habersetzer F, et al.Anti-pseudo-PCNA type 1 (anti-SG2NA) pattern: Track down Cancer, not SLE. Joint Bone Spine. 2016;83:330-4.
2.Muro Y, Chan EKL, Landberg G, Tan EM. A cell-cycle nuclear autoantigen containing WD-40 motifs expressed mainly in S and G2 phase cells. Biochem Biophys Res Commun. 1995;207:1029-37.
3.Landberg G, Tan EM. Characterization of a DNA-binding nuclear autoantigen mainly associated with S phase and G2 cells.Exp Cell Res. 1994;212:255-61.
4.Fritzler MJ, Muro Y, Klotz W, Herold M, Andrade LEC, Grecco M, Satoh M, Choi M, et al.Striatin is a human autoantigen but it is not associated with the S and G2 phase nuclear antigen (SG2NA) staining pattern. 2025;in preparation.
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二级信息Second level information
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二级信息参考文献Second level information references
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FAQ
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