临床相关性
一级信息 关于临床相关性和缩写列表 |
Clinical Relevance
First level information About Clinical Relevance & List of Abbreviations |
► AC-27核型对任何疾病的阳性预测值均较低(116) ►在常规血清学诊断中非常少见(117) ►所识别的抗原包括 CENP-E、CENP-F、TD60、MSA36、KIF-14、MKLP-1、MPP1/KIF20B和 INCENP;这些自身抗体的特异性免疫检测试剂目前尚未商品化 (116, 118, 119) |
► The AC-27 pattern has low positive predictive value for any disease (116) ► Found very infrequently in a routine serology diagnostic setting (117) ► Antigens recognized include, among other, CENP-E, CENP-F, TD60, MSA36, KIF-14, MKLP-1, MPP1/KIF20B, and INCENP; specific immunoassays for these autoantibodies are currently not commercially available (116, 118, 119) |
一级信息参考文献 | First level information references |
116. Rattner JB, Mack GJ, Fritzler MJ. Autoantibodies to components of the mitotic apparatus. Mol Biol Rep 1998;25:143–55. 117. Vermeersch P, Bossuyt X. Prevalence and clinical significance of rare antinuclear antibody patterns. Autoimmun Rev 2013;12:998–1003. 118. Humbel RLConrad K, ed. Autoantibodies to mitotic cells. In Dresden autoantibody symposium. Dresden Germany: Pabst Science, 2013: 327–39. 119. Rodriguez-Bayona B, Ruchaud S, Rodriguez C, et al. Autoantibodies against the chromosomal passenger protein INCENP found in a patient with Graham Little-Piccardi-Lassueur syndrome. J Autoimmune Dis 2007;4. |
116. Rattner JB, Mack GJ, Fritzler MJ. Autoantibodies to components of the mitotic apparatus. Mol Biol Rep 1998;25:143–55. 117. Vermeersch P, Bossuyt X. Prevalence and clinical significance of rare antinuclear antibody patterns. Autoimmun Rev 2013;12:998–1003. 118. Humbel RLConrad K, ed. Autoantibodies to mitotic cells. In Dresden autoantibody symposium. Dresden Germany: Pabst Science, 2013: 327–39. 119. Rodriguez-Bayona B, Ruchaud S, Rodriguez C, et al. Autoantibodies against the chromosomal passenger protein INCENP found in a patient with Graham Little-Piccardi-Lassueur syndrome. J Autoimmune Dis 2007;4. |
二级信息 | Second level information |
►在系统性硬化症、雷诺现象和恶性肿瘤的患者中偶有检出(10-12) ►对 CENP-E、CENP-F、TD60、MSA36、KIF-14和MKLP-1的自身抗体在系统性硬化症 (局限型和弥漫型)、系统性红斑狼疮和恶性肿瘤患者中均有报道 (13,14) ►INCENP自身抗体曾在一例假性斑秃-毛周角化综合征患者中被检出 (15) ►MPP1/KIF20B (M期磷蛋白1) 自身抗体曾在特发性共济失调、其他神经综合征和阵发性夜间血红蛋白尿的患者中被检出 (16,17) 注:大多数报道都描述了自身抗体直接与特异性抗原结合(即抗原特异性免疫分析),实际并未显示与AC-27模式相关性;这些自身抗体的特异性免疫检测试剂目前尚未商品化。 |
► Incidentally described in patients with SSc, Raynaud’s phenomenon, and malignancy (10-12) ► Autoantibodies to CENP-E, CENP-F, TD60, MSA36, KIF-14, and MKLP-1 have been described in patients with SSc (limited and diffuse), SLE, and malignancies (13, 14) ► Autoantibodies to INCENP have been described in a single patient with Graham-Little-Piccardi-Lasseur Syndrome (15) ► Autoantibodies to MPP1 /KIF20B (M-phase phosphoprotein 1) have been described in patients with idiopathic ataxia, other neurological syndromes and paroxysmal nocturnal haemoglobinuria (16, 17) Notes: Most reports describe autoantibodies directly binding to specific antigens (i.e., antigen-specific immunoassays) and do not actually show correlations with the AC-27 pattern as such; specific immunoassays for these autoantibodies are currently not commercially available. |
二级信息参考文献 | Second level information references |
10. Fritzler MJ, Ayer LM, Gohill J, et al. An antigen in metaphase chromatin and the midbody of mammalian cells binds to scleroderma sera. J Rheumatol 1987;14:291-4. 11. Tausche AK, Conrad K, Seidel W, et al. Anti-midbody antibodies as a possible predictive factor for a special limited or abortive form of systemic sclerosis? Ann Rheum Dis 2005;64:1237-8. 12. Vermeersch P, Bossuyt X. Prevalence and clinical significance of rare antinuclear antibody patterns. Autoimmun Rev 2013;12:998-1003. 13. Rattner JB, Mack GJ, Fritzler MJ. Autoantibodies to components of the mitotic apparatus. Mol Biol Rep 1998;25:143-55. 14. Humbel RL. Autoantibodies to mitotic cells. in Dresden Autoantibody Symposium (eds. Conrad, K., et al.) 327-39 (Pabst Science, Dresden, Germany, 2013). 15. Rodriguez-Bayona B, Ruchaud S, Rodriguez C, et al. Autoantibodies against the chromosomal passenger protein INCENP found in a patient with Graham Little-Piccardi-Lassueur syndrome. J Autoimmune Dis 2007;4:1. 16. Fritzler MJ, Kerfoot SM, Feasby TE, et al. Autoantibodies from patients with idiopathic ataxia bind to M-phase phosphoprotein 1 (MPP-1). J Invest Med 2000;48:28-39. 17. Alahmad A, Preuss KD, Schenk J, et al. Desmoplakin and KIF20B as target antigens in patients with paroxysmal nocturnal haemoglobinuria. Br J Haematol 2010;151:273-80. |
10. Fritzler MJ, Ayer LM, Gohill J, et al. An antigen in metaphase chromatin and the midbody of mammalian cells binds to scleroderma sera. J Rheumatol 1987;14:291-4. 11. Tausche AK, Conrad K, Seidel W, et al. Anti-midbody antibodies as a possible predictive factor for a special limited or abortive form of systemic sclerosis? Ann Rheum Dis 2005;64:1237-8. 12. Vermeersch P, Bossuyt X. Prevalence and clinical significance of rare antinuclear antibody patterns. Autoimmun Rev 2013;12:998-1003. 13. Rattner JB, Mack GJ, Fritzler MJ. Autoantibodies to components of the mitotic apparatus. Mol Biol Rep 1998;25:143-55. 14. Humbel RL. Autoantibodies to mitotic cells. in Dresden Autoantibody Symposium (eds. Conrad, K., et al.) 327-39 (Pabst Science, Dresden, Germany, 2013). 15. Rodriguez-Bayona B, Ruchaud S, Rodriguez C, et al. Autoantibodies against the chromosomal passenger protein INCENP found in a patient with Graham Little-Piccardi-Lassueur syndrome. J Autoimmune Dis 2007;4:1. 16. Fritzler MJ, Kerfoot SM, Feasby TE, et al. Autoantibodies from patients with idiopathic ataxia bind to M-phase phosphoprotein 1 (MPP-1). J Invest Med 2000;48:28-39. 17. Alahmad A, Preuss KD, Schenk J, et al. Desmoplakin and KIF20B as target antigens in patients with paroxysmal nocturnal haemoglobinuria. Br J Haematol 2010;151:273-80. |
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