ICAP
AC-26 - NuMA型
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同义词 MSA-1,亲中心体蛋白 MSA-1, centrophilin
描述

细胞核纺锤丝斑点状染色

Nuclear speckled staining with spindle fibers.

抗原相关性 核有丝分裂器蛋白 NuMA
临床相关性
一级信息
关于临床相关性和缩写列表
Clinical Relevance
First level information
About Clinical Relevance & List of Abbreviations

►大约一半的AC-26核型患者具有系统性自身免疫性风湿疾病的临床特征 (干燥综合征、系统性红斑狼疮、未分化的结缔组织病、局限型系统性硬化症、或类风湿性关节炎);AC-26核型在器官特异性自身免疫性疾病的患者中也被观测到,在非自身免疫性疾病中更少见,尤其是在抗体滴度较低时 (109, 111–114)

►在常规血清学诊断中非常少见 (109)

►所识别的抗原包括NuMA、亲中心体蛋白 (centrophilin)、SP-H抗原和NMP-22;这些自体抗体的特异性免疫检测试剂目前尚未商品化 (115)


► Approximately one-half of the patients with the AC-26 pattern have clinical features of a SARD (SjS, SLE, UCTD, limited SSc, or RA); the AC-26 pattern is also observed in patients with organ-specific autoimmune diseases and less frequently in non-autoimmune conditions, especially when in low titer (109, 111–114)

► Found very infrequently in a routine serology diagnostic setting (109)

► Antigens recognized include NuMA, centrophilin, SP-H antigen and NMP-22; specific immunoassays for these autoantibodies are currently not commercially available (115)


一级信息参考文献 First level information references

109. Mozo L, Gutiérrez C, Gómez J, Gómez Jesús. Antibodies to mitotic spindle apparatus: clinical significance of NuMA and HsEg5 autoantibodies. J Clin Immunol 2008;28:285–90.

111. Szalat R, Ghillani-Dalbin P, Jallouli M, et al. Anti-NuMA1 and anti-NuMA2 (anti-HsEg5) antibodies: clinical and Immunological features: a propos of 40 new cases and review of the literature. Autoimmun Rev 2010;9:652–6.

112. Grypiotis P, Ruffatti A, Tonello M, et al. [Clinical significance of fluoroscopic patterns specific for the mitotic spindle in patients with rheumatic diseases]. Reumatismo 2002;54:232–7.

113. Price CM, McCarty GA, Pettijohn DE. NuMA protein is a human autoantigen. Arthritis Rheum 1984;27:774–9.

114. Bonaci-Nikolic B, Andrejevic S, Bukilica M, et al. Autoantibodies to mitotic apparatus: association with other autoantibodies and their clinical significance. J Clin Immunol 2006;26:438–46.

115. Compton DA, Szilak I, Cleveland DW. Primary structure of NuMA, an intranuclear protein that defines a novel pathway for segregation of proteins at mitosis. J Cell Biol 1992;116:1395–408.


109. Mozo L, Gutiérrez C, Gómez J, Gómez Jesús. Antibodies to mitotic spindle apparatus: clinical significance of NuMA and HsEg5 autoantibodies. J Clin Immunol 2008;28:285–90.

111. Szalat R, Ghillani-Dalbin P, Jallouli M, et al. Anti-NuMA1 and anti-NuMA2 (anti-HsEg5) antibodies: clinical and Immunological features: a propos of 40 new cases and review of the literature. Autoimmun Rev 2010;9:652–6.

112. Grypiotis P, Ruffatti A, Tonello M, et al. [Clinical significance of fluoroscopic patterns specific for the mitotic spindle in patients with rheumatic diseases]. Reumatismo 2002;54:232–7.

113. Price CM, McCarty GA, Pettijohn DE. NuMA protein is a human autoantigen. Arthritis Rheum 1984;27:774–9.

114. Bonaci-Nikolic B, Andrejevic S, Bukilica M, et al. Autoantibodies to mitotic apparatus: association with other autoantibodies and their clinical significance. J Clin Immunol 2006;26:438–46.

115. Compton DA, Szilak I, Cleveland DW. Primary structure of NuMA, an intranuclear protein that defines a novel pathway for segregation of proteins at mitosis. J Cell Biol 1992;116:1395–408.


二级信息 Second level information


None

二级信息参考文献 Second level information references


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Online since 19 May 2015