ICAP
AC-22 - 胞浆极性/高尔基体样型
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同义词 None
描述

在细胞浆两级,靠近细胞核的一侧呈现不连续斑点或颗粒样染色。

Discontinuous speckled or granular perinuclear ribbon-like staining with polar distribution in the cytoplasm. e.g. anti-giantin, anti-golgin-245.

抗原相关性 巨蛋白/巨高尔基蛋白 giantin/macrogolgin, golgin-95/GM130, golgin-160, golgin-97, golgin-245
临床相关性
一级信息
关于临床相关性和缩写列表
Clinical Relevance
First level information
About Clinical Relevance & List of Abbreviations

►在少数患有多种病症的患者中有检出

►所识别的抗原包括巨蛋白/巨高尔基蛋白和不同的高尔基体蛋白分子;用于检测针对高尔基体特异抗原的自身抗体的特异性免疫检测试剂目前尚未商品化 (85)

► Found in small numbers of patients with a variety of conditions

► Antigens recognized include giantin/macrogolgin and distinct golgin molecules; specific immunoassays to detect autoantibodies directed to specific Golgi antigens are currently not commercially available (85)


一级信息参考文献 First level information references

85. Stinton LM, Eystathioy T, Selak S, et al. Autoantibodies to protein transport and messenger RNA processing pathways: endosomes, lysosomes, Golgi complex, proteasomes, assemblyosomes, exosomes, and GW bodies. Clin Immunol 2004;110:30–44.

85. Stinton LM, Eystathioy T, Selak S, et al. Autoantibodies to protein transport and messenger RNA processing pathways: endosomes, lysosomes, Golgi complex, proteasomes, assemblyosomes, exosomes, and GW bodies. Clin Immunol 2004;110:30–44.

二级信息 Second level information

AC-22核型已在少数有多种病症的患者中道,包括干燥合征、斑狼疮、湿性关炎、混合型结缔组织病、肉芽性血管炎、性小调、瘤性小脑变性、成人斯蒂尔氏病,以及病毒感染,包括HIV和EBV (29, 36-38)

尽管可能会受到转诊模式的影响,一项研究得出结论,AC-22核型在临床上与系统性自身免疫性风湿疾病无关,因为在过去10年收集的20例AC-22阳性病例以及0-10年的临床随访中,仅1例诊断为干燥综合征,2例为类风湿性关节炎;其余病例被诊断为多种疾病,包括2例上皮细胞癌 (37)

►AC-22核型在一般人群中很少见 (39)


► The AC-22 pattern has been reported in small numbers of patients with a variety of conditions, including SjS, SLE, RA, MCTD, GPA, idiopathic cerebellar ataxia, paraneoplastic cerebellar degeneration, adult Still’s disease, and viral infections including HIV and EBV (29, 36-38)

► Although possibly biased by the referral pattern, one study concluded that the AC-22 pattern is not clinically associated with SARD as there were only 1 SjS and 2 RA diagnoses among their 20 AC-22 positive cases collected over 10-years and a clinical follow-up observation ranging from 0 – 10 years; the remaining cases showed diverse diagnoses including 2 carcinomas (37)

► The AC-22 pattern is rare in the general population (39)


二级信息参考文献 Second level information references

29. Stinton LM, Eystathioy T, Selak S, et al. Autoantibodies to protein transport and messenger RNA processing pathways: endosomes, lysosomes, Golgi complex, proteasomes, assemblyosomes, exosomes, and GW bodies. Clin Immunol 2004;110:30-44.

36. Fritzler MJ, Etherington J, Sokolu, C, et al. Antibodies from patients with autoimmune disease react with a cytoplasmic antigen in the Golgi apparatus. J Immunol 1984;132:2904-8.

37. Vermeersch P, Van den Bergh K, Blockmans D, et al. Anti-Golgi autoantibodies are not clinically associated with systemic autoimmune diseases. Ann Rheum Dis 2011;70:234-5.

38. Staub HL, Souza F, Chan EKL, et al. Anti-Golgi antibodies in adult Still's disease. Clin Exp Rheumatol 2003;21:275-6.

39. Satoh M, Chan EKL, Ho LA, et al. Prevalence and sociodemographic correlates of antinuclear antibodies in the United States. Arthritis Rheum 2012;64:2319-27.

29. Stinton LM, Eystathioy T, Selak S, et al. Autoantibodies to protein transport and messenger RNA processing pathways: endosomes, lysosomes, Golgi complex, proteasomes, assemblyosomes, exosomes, and GW bodies. Clin Immunol 2004;110:30-44.

36. Fritzler MJ, Etherington J, Sokolu, C, et al. Antibodies from patients with autoimmune disease react with a cytoplasmic antigen in the Golgi apparatus. J Immunol 1984;132:2904-8.

37. Vermeersch P, Van den Bergh K, Blockmans D, et al. Anti-Golgi autoantibodies are not clinically associated with systemic autoimmune diseases. Ann Rheum Dis 2011;70:234-5.

38. Staub HL, Souza F, Chan EKL, et al. Anti-Golgi antibodies in adult Still's disease. Clin Exp Rheumatol 2003;21:275-6.

39. Satoh M, Chan EKL, Ho LA, et al. Prevalence and sociodemographic correlates of antinuclear antibodies in the United States. Arthritis Rheum 2012;64:2319-27.


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Online since 19 May 2015