临床相关性
一级信息 关于临床相关性和缩写列表 |
Clinical Relevance
First level information About Clinical Relevance & List of Abbreviations |
►AC-29核型对系统性硬化症具有高度特异性,特别是弥漫性皮肤型系统性硬化症和更具侵袭形式的系统性硬化症 (14, 18, 23) ►如果临床上怀疑有系统性硬化症,建议对抗拓扑异构酶I (之前称为Scl-70) 抗体进行随访检测;抗拓扑异构酶I抗体被包括在系统性硬化症的分类标准中,而抗原则被包括在常规ENA谱中 (8, 23, 79) |
► The AC-29 pattern is highly specific for SSc, in particular with diffuse cutaneous SSc and more aggressive forms of SSc (14, 18, 23) ► If SSc is clinically suspected, it is recommended to perform a follow-up test for anti-Topoisomerase I (formerly Scl-70) antibodies; the anti-Topoisomerase I antibodies are included in the classification criteria for SSc and the antigen is included in routine ENA profiles (8, 23, 79) |
一级信息参考文献 | First level information references |
8. van den Hoogen F, Khanna D, Fransen J, et al. 2013 classification criteria for systemic sclerosis: an American College of rheumatology/European League against rheumatism collaborative initiative. Ann Rheum Dis 2013;72:1747–55. 14. Andrade LEC, Klotz W, Herold M, et al. International consensus on antinuclear antibody patterns: definition of the ac-29 pattern associated with antibodies to DNA topoisomerase I. Clin Chem Lab Med 2018;56:1783–8. 18. Dellavance A, Gallindo C, Soares MG, et al. Redefining the Scl-70 indirect immunofluorescence pattern: autoantibodies to DNA topoisomerase I yield a specific compound immunofluorescence pattern. Rheumatology 2009;48:632–7. 23. Johnson SR, Fransen J, Khanna D, et al. Validation of potential classification criteria for systemic sclerosis. Arthritis Care Res 2012;64:358–67. 79. Basu D, Reveille JD. Anti-scl-70. Autoimmunity 2005;38:65–72. |
8. van den Hoogen F, Khanna D, Fransen J, et al. 2013 classification criteria for systemic sclerosis: an American College of rheumatology/European League against rheumatism collaborative initiative. Ann Rheum Dis 2013;72:1747–55. 14. Andrade LEC, Klotz W, Herold M, et al. International consensus on antinuclear antibody patterns: definition of the ac-29 pattern associated with antibodies to DNA topoisomerase I. Clin Chem Lab Med 2018;56:1783–8. 18. Dellavance A, Gallindo C, Soares MG, et al. Redefining the Scl-70 indirect immunofluorescence pattern: autoantibodies to DNA topoisomerase I yield a specific compound immunofluorescence pattern. Rheumatology 2009;48:632–7. 23. Johnson SR, Fransen J, Khanna D, et al. Validation of potential classification criteria for systemic sclerosis. Arthritis Care Res 2012;64:358–67. 79. Basu D, Reveille JD. Anti-scl-70. Autoimmunity 2005;38:65–72. |
二级信息 | Second level information |
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None |
二级信息参考文献 | Second level information references |
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None |
FAQ |
为了正确判读AC-29,必须评估所有与AC-29模型相关的五种亚细胞结构域染色吗?换句话说,如果只满足五个条件中的部分,是否可以归类为AC-29 ? |