►在常规血清学诊断中非常少见

►所识别的抗原包括α-辅肌动蛋白和抗黏着斑蛋白；这些自身抗体的特异性免疫检测试剂目前尚未商品化

► Found very infrequently in a routine serology diagnostic setting

► Antigens recognized include α-actinin and vinculin; specific immunoassays for these autoantibodies are currently not commercially available

无

None

抗α-辅肌动蛋白的自身抗体

►据报道，在系统性红斑狼疮和狼疮性肾炎中，有交叉反应的抗α-肌动蛋白和抗dsDNA抗体具有致病性 (21)

►据报道，部分抗细胞膜抗体谱是狼疮性肾炎患者的特征；也是无肾脏受累的狼疮肾炎患者区分的一种生物标志物 (22, 23)

►据报道，在相当高比例 (~40%) 的1型自身免疫性肝炎患者中检出该抗体，并且与更严重的疾病、临床和组织病理的疾病活动性、治疗反应的预测性以及和抗ssDNA抗体的双阳性相关联 (24-26)

抗黏着斑蛋白的自身抗体：

►据报道在31例慢性炎性脱髓鞘神经病患者中有2例检出该抗体(27)

注：大多数报道描述了与特异性抗原直接结合的自身抗体 (即，抗原特异性免疫检测法)，实际上并未显示与AC-17核型的相关性；这些自身抗体的特异性免疫检测试剂目前尚未商品化。

utoantibodies to α-actinin:

► In SLE and lupus nephritis cross-reactive anti-α-actinin and anti-dsDNA autoantibodies have been reported as pathogenic (21)

► Reported as part of the anti-cell membrane antibody spectrum that characterize patients with lupus nephritis; also reported as a biomarker to differentiate patients with lupus nephritis from those without renal involvement (22, 23)

► Reported with relatively high prevalence (~40%) in patients with AIH type 1 and associated with more severe disease, clinical and histological disease activity, predictor of therapeutic response, and double positivity with anti-ssDNA antibodies (24-26)

Autoantibodies to vinculin:

► Reported in 2 of 31 patients with chronic inflammatory demyelinating neuropathy (27)

Notes: Most reports describe autoantibodies directly binding to specific antigens (i.e. antigen-specific immunoassays) and none actually shows correlations with the AC-17 pattern as such; specific immunoassays for these autoantibodies are currently not commercially available.

21. Zhao Z, Weinstein E, Tuzova M, et al. Cross-reactivity of human lupus anti-DNA antibodies with alpha-actinin and nephritogenic potential. Arthritis Rheum 2005;52:522-30.

22. Seret G, Canas F, Pougnet-Di Costanzo L, et al. Anti-alpha-actinin antibodies are part of the anti-cell membrane antibody spectrum that characterize patients with lupus nephritis. J Autoimmun 2015;61:54-61.

23. Zhang WH, Pan HF, Zhao XF, et al. Anti-alpha-actinin antibodies in relation to new-onset systemic lupus erythematosus and lupus nephritis. Mol Biol Rep 2010;37:1341-5.

24. Gueguen P, Dalekos G, Nousbaum JB, et al. Double reactivity against actin and alpha-actinin defines a severe form of autoimmune hepatitis type 1. J Clin Immunol 2006;26:495-505.

25. Renaudineau Y, Dalekos GN, Gueguen P, et al. Anti-alpha-actinin antibodies cross-react with anti-ssDNA antibodies in active autoimmune hepatitis. Clin Rev Allergy Immunol 2008);34:321-5.

26. Zachou K, Oikonomou K, Renaudineau Y, et al. Anti-alpha actinin antibodies as new predictors of response to treatment in autoimmune hepatitis type 1. Aliment Pharmacol Ther 2012;35:116-25.

27. Beppu M, Sawai S, Satoh M, et al. Autoantibodies against vinculin in patients with chronic inflammatory demyelinating polyneuropathy. J Neuroimmunol 2015;287:9-15.

21. Zhao Z, Weinstein E, Tuzova M, et al. Cross-reactivity of human lupus anti-DNA antibodies with alpha-actinin and nephritogenic potential. Arthritis Rheum 2005;52:522-30.

22. Seret G, Canas F, Pougnet-Di Costanzo L, et al. Anti-alpha-actinin antibodies are part of the anti-cell membrane antibody spectrum that characterize patients with lupus nephritis. J Autoimmun 2015;61:54-61.

23. Zhang WH, Pan HF, Zhao XF, et al. Anti-alpha-actinin antibodies in relation to new-onset systemic lupus erythematosus and lupus nephritis. Mol Biol Rep 2010;37:1341-5.

24. Gueguen P, Dalekos G, Nousbaum JB, et al. Double reactivity against actin and alpha-actinin defines a severe form of autoimmune hepatitis type 1. J Clin Immunol 2006;26:495-505.

25. Renaudineau Y, Dalekos GN, Gueguen P, et al. Anti-alpha-actinin antibodies cross-react with anti-ssDNA antibodies in active autoimmune hepatitis. Clin Rev Allergy Immunol 2008);34:321-5.

26. Zachou K, Oikonomou K, Renaudineau Y, et al. Anti-alpha actinin antibodies as new predictors of response to treatment in autoimmune hepatitis type 1. Aliment Pharmacol Ther 2012;35:116-25.

27. Beppu M, Sawai S, Satoh M, et al. Autoantibodies against vinculin in patients with chronic inflammatory demyelinating polyneuropathy. J Neuroimmunol 2015;287:9-15.