ICAP
AC-11 - 光滑核膜型
  简体中文 English
同义词 核边缘,核膜,膜状 nuclear rim, nuclear membrane, membranous
描述

细胞核呈现均匀荧光,核周增强;分裂中期和后期细胞的染色体阴性;临近细胞相触部位荧光增强。例如抗板层素B抗体。

Homogeneous staining of the nucleus with greater intensity at its outer rim and no staining at the metaphase and anaphase chromatin plates. There is a peculiar accentuation of the fluorescence at the points where adjacent cells touch each other. e.g. anti-lamin B.

抗原相关性 板层素A,B,C,或板层素相关蛋白 lamins A,B,C, or lamin-associated proteins
临床相关性
一级信息
关于临床相关性和缩写列表
Clinical Relevance
First level information
About Clinical Relevance & List of Abbreviations

►AC-11核型很少在常规的自身抗体检测中发现,在自身免疫性细胞减少症、自身免疫性肝病、带状硬皮病、抗磷脂综合征和系统性自身免疫性风湿疾病中都有描述;目前关于临床相关性的信息主要基于病例报告和小群体研究(58-60)

►被识别的抗原包括lamins (A、B、C)和LAP-2;目前还没有针对这些自身抗体的特异性免疫检测商品化试剂盒(58-60)

► The AC-11 pattern is infrequently found in routine autoantibody testing and has been described in autoimmune-cytopenias, autoimmune liver diseases, linear scleroderma, APS, and SARD; current information on clinical associations is based mainly on case reports and small cohorts (58–60)

► Antigens recognized include lamins (A, B, C) and LAP-2; specific immunoassays for these autoantibodies are currently not commercially available (58–60)


一级信息参考文献 First level information references

58. Coppo P, Clauvel JP, Bengoufa D, et al. Autoimmune cytopenias associated with autoantibodies to nuclear envelope polypeptides. Am J Hematol 2004;77:241–9.

59. Konstantinov K, Foisner R, Byrd D, et al. Integral membrane proteins associated with the nuclear lamina are novel autoimmune antigens of the nuclear envelope. Clin Immunol Immunopathol 1995;74:89–99.

60. Reeves WH, Chaudhary N, Salerno A, et al. Lamin B autoantibodies in sera of certain patients with systemic lupus erythematosus. J Exp Med 1987;165:750–62.


58. Coppo P, Clauvel JP, Bengoufa D, et al. Autoimmune cytopenias associated with autoantibodies to nuclear envelope polypeptides. Am J Hematol 2004;77:241–9.

59. Konstantinov K, Foisner R, Byrd D, et al. Integral membrane proteins associated with the nuclear lamina are novel autoimmune antigens of the nuclear envelope. Clin Immunol Immunopathol 1995;74:89–99.

60. Reeves WH, Chaudhary N, Salerno A, et al. Lamin B autoantibodies in sera of certain patients with systemic lupus erythematosus. J Exp Med 1987;165:750–62.


二级信息 Second level information


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二级信息参考文献 Second level information references


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Online since 19 May 2015