临床相关性
一级信息 关于临床相关性和缩写列表 |
Clinical Relevance
First level information About Clinical Relevance & List of Abbreviations |
►AC-7核型对疾病的阳性预测值较低(40,41)。 ►抗原主要分布于核点中,这些核点含有p80-螺旋蛋白与SMN复合体等。目前针对这些自身抗体的特异性免疫检测尚无商品化试剂(42,43)。 |
► The AC-7 pattern has low positive predictive value for any disease (40, 41) ► Antigens primarily localized in the dots include p80-coilin and SMN complex; specific immunoassays for these autoantibodies are currently not commercially available (42, 43) |
一级信息参考文献 | First level information references |
40. Onouchi H, Muro Y, Tomita Y. Clinical features and IgG subclass distribution of anti-p80 coilin antibodies. J Autoimmun 1999;13:225–32. 41. Fujimoto M, Kikuchi K, Tamaki T, et al. Distribution of anti-p80-coilin autoantibody in collagen diseases and various skin diseases. Br J Dermatol 1997;137:916–20. 42. Andrade LE, Chan EK, Raska I, et al. Human autoantibody to a novel protein of the nuclear coiled body: immunological characterization and cDNA cloning of p80-coilin. J Exp Med 1991;173:1407–19. 43. Satoh M, Chan JY, Ross SJ, et al. Autoantibodies to survival of motor neuron complex in patients with polymyositis: immunoprecipitation of D, E, F, and G proteins without other components of small nuclear ribonucleoproteins. Arthritis Rheum 2011;63:1972–8. |
40. Onouchi H, Muro Y, Tomita Y. Clinical features and IgG subclass distribution of anti-p80 coilin antibodies. J Autoimmun 1999;13:225–32. 41. Fujimoto M, Kikuchi K, Tamaki T, et al. Distribution of anti-p80-coilin autoantibody in collagen diseases and various skin diseases. Br J Dermatol 1997;137:916–20. 42. Andrade LE, Chan EK, Raska I, et al. Human autoantibody to a novel protein of the nuclear coiled body: immunological characterization and cDNA cloning of p80-coilin. J Exp Med 1991;173:1407–19. 43. Satoh M, Chan JY, Ross SJ, et al. Autoantibodies to survival of motor neuron complex in patients with polymyositis: immunoprecipitation of D, E, F, and G proteins without other components of small nuclear ribonucleoproteins. Arthritis Rheum 2011;63:1972–8. |
二级信息 | Second level information |
►抗p80-螺旋蛋白抗体可能罕见于系统性红斑狼疮、系统性硬化症(局限型),以及干燥综合征等(15-17)。 ►有报道于自身免疫性肌病患者或系统性硬化症-自身免疫性肌病重叠综合征患者中分离到了抗SMN抗体,同时未分离到抗snRNP抗体(18)。 ►特异性的抗p-80螺旋蛋白抗体与抗SMN复合体抗体可运用蛋白免疫印迹法、重组蛋白与免疫沉淀的固相免疫法进行检测确认(15,18,19)。 注:多数研究报道的是直接结合特异性抗原的自身抗体(例如,通过抗原特异性免疫检测法检测),并且未报道这些抗原与AC-7明确相关。目前尚无针对这些自身抗体的商品化免疫检测试剂。 |
► Anti‐p80‐coilin antibodies may rarely occur in SLE, (localized linear) SSc, and SjS (15‐17) ► Isolated (without anti‐snRNPs) anti‐SMN antibodies are reported in patients with AIM or SSc‐AIM overlap syndrome (18) ► The specificity of antibodies to p80‐coilin and the SMN complex can be confirmed by Western blot, solid phase immunoassays using recombinant proteins and immunoprecipitation (15, 18, 19) Notes: Most reports describe autoantibodies directly binding to specific antigens (i.e. antigen‐specific immunoassays) and do not actually show clear correlations with the AC‐7 pattern as such; specific immunoassays for these autoantibodies are currently not commercially available. |
二级信息参考文献 | Second level information references |
15. Andrade LE, Chan EK, Raska I, et al. Human autoantibody to a novel protein of the nuclear coiled body: immunological characterization and cDNA cloning of p80‐coilin. J Exp Med 1991;173:1407‐19. 16. Fujimoto M, Kikuchi K, Tamaki T, et al. Distribution of anti‐p80‐coilin autoantibody in collagen diseases and various skin diseases. Br J Dermatol 1997;137:916‐20. 17. Onouchi H, Muro Y, Tomita Y. Clinical features and IgG subclass distribution of anti‐p80 coilin antibodies. J Autoimmun 1999;13:225‐32. 18. Satoh M, Chan JY, Ross SJ, et al. Autoantibodies to survival of motor neuron (SMN) complex in patients with polymyositis – immunoprecipitation of D‐EF‐G without other components of small nuclear ribonucleoproteins. Arthritis Rheum 2011;63:1972‐8. 19. Amlani A, Hazlewood GS, Hamilton L, et al. Autoantibodies to the survival of motor neuron complex in a patient with necrotizing autoimmune myopathy. Rheumatology 2018;57:199‐200. |
15. Andrade LE, Chan EK, Raska I, et al. Human autoantibody to a novel protein of the nuclear coiled body: immunological characterization and cDNA cloning of p80‐coilin. J Exp Med 1991;173:1407‐19. 16. Fujimoto M, Kikuchi K, Tamaki T, et al. Distribution of anti‐p80‐coilin autoantibody in collagen diseases and various skin diseases. Br J Dermatol 1997;137:916‐20. 17. Onouchi H, Muro Y, Tomita Y. Clinical features and IgG subclass distribution of anti‐p80 coilin antibodies. J Autoimmun 1999;13:225‐32. 18. Satoh M, Chan JY, Ross SJ, et al. Autoantibodies to survival of motor neuron (SMN) complex in patients with polymyositis – immunoprecipitation of D‐EF‐G without other components of small nuclear ribonucleoproteins. Arthritis Rheum 2011;63:1972‐8. 19. Amlani A, Hazlewood GS, Hamilton L, et al. Autoantibodies to the survival of motor neuron complex in a patient with necrotizing autoimmune myopathy. Rheumatology 2018;57:199‐200. |
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