临床相关性
一级信息 关于临床相关性和缩写列表 |
Clinical Relevance
First level information About Clinical Relevance & List of Abbreviations |
►见于系统性红斑狼疮、慢性自身免疫性肝炎或幼年特发性关节炎的患者中 ►如果临床上怀疑系统性红斑狼疮,建议进一步检测dsDNA抗体或dsDNA/组蛋白复合物(核小体/染色质)抗体;系统性红斑狼疮的分类标准中包括抗dsDNA抗体(15,16) ►如果怀疑是慢性自身免疫性肝炎或幼年特发性关节炎,则不建议进行进一步检测,因为目前已知的有关AC-1核型的靶抗原尚未完全明确(17) 注:虽然拓扑异构酶I(以前的Scl-70)的自身抗体可能被报告为核均质的,但它们通常显示出一种复合的AC-29 的HEp-2 荧光核型;因此,临床怀疑系统性硬化症的患者可能需要对该抗体进行进一步检测(14,18) 尽管AC-1是慢性自身免疫性肝炎中最常见的核型,但其他HEp-2 荧光核型也可能出现,但对于这些核型的靶抗原也尚未完全明确(19) |
▶Found in patients with SLE, chronic autoimmune hepatitis or juvenile idiopathic arthritis ▶If
SLE is clinically suspected, it is recommended to perform a follow-up
test for anti-dsDNA antibodies, alone or in combination with
dsDNA/histone complexes (nucleosomes/chromatin); anti-dsDNA antibodies
are included in the classification criteria for SLE (15, 16) ▶If chronic autoimmune hepatitis or juvenile idiopathic arthritis is suspected, follow-up testing is not recommended because the respective autoantigens revealing the AC-1 pattern are not completely defined (17) Notes:
Although autoantibodies to Topoisomerase I (formerly Scl-70) may be
reported as nuclear homogeneous, they typically reveal a composite AC-29
HEp-2 IIFA pattern; as such, clinical suspicion of SSc may warrant
follow-up testing for reactivity to this antigen (14, 18) |
一级信息参考文献 | First level information references |
14.Andrade
LEC, Klotz W, Herold M, et al. International consensus on antinuclear
antibody patterns: definition of the ac-29 pattern associated with
antibodies to DNA topoisomerase I. Clin Chem Lab Med 2018;56:1783–8. 15.Conrad
K, Schössler W, Hiepe F. Autoantibodies in systemic autoimmune
diseases: a diagnostic reference. 2. 3th edn. Autoantigens
autoantibodies autoimmunity, 2015. 16.Petri
M, Orbai AM, Alarcón GS, et al. Derivation and validation of the
systemic lupus international collaborating clinics classification
criteria for systemic lupus erythematosus. Arthritis Rheum
2012;64:2677–86. 17.Conrad
K, Schössler W, Hiepe F. Autoantibodies in organ specific autoimmune
diseases. a diagnostic reference. 8. 2th edn. Autoantigens
autoantibodies autoimmunity, 2017. 18.Dellavance
A, Gallindo C, Soares MG, et al. Redefining the Scl-70 indirect
immunofluorescence pattern: autoantibodies to DNA topoisomerase I yield a
specific compound immunofluorescence pattern. Rheumatology
2009;48:632–7. 19.European
Association for the Study of the Liver. EASL clinical practice
guidelines: autoimmune hepatitis. J Hepatol 2015;63:971–1004. |
14.Andrade
LEC, Klotz W, Herold M, et al. International consensus on antinuclear
antibody patterns: definition of the ac-29 pattern associated with
antibodies to DNA topoisomerase I. Clin Chem Lab Med 2018;56:1783–8. 15.Conrad
K, Schössler W, Hiepe F. Autoantibodies in systemic autoimmune
diseases: a diagnostic reference. 2. 3th edn. Autoantigens
autoantibodies autoimmunity, 2015. 16.Petri
M, Orbai AM, Alarcón GS, et al. Derivation and validation of the
systemic lupus international collaborating clinics classification
criteria for systemic lupus erythematosus. Arthritis Rheum
2012;64:2677–86. 17.Conrad
K, Schössler W, Hiepe F. Autoantibodies in organ specific autoimmune
diseases. a diagnostic reference. 8. 2th edn. Autoantigens
autoantibodies autoimmunity, 2017. 18.Dellavance
A, Gallindo C, Soares MG, et al. Redefining the Scl-70 indirect
immunofluorescence pattern: autoantibodies to DNA topoisomerase I yield a
specific compound immunofluorescence pattern. Rheumatology
2009;48:632–7. 19.European
Association for the Study of the Liver. EASL clinical practice
guidelines: autoimmune hepatitis. J Hepatol 2015;63:971–1004. |
二级信息 | Second level information |
无 |
None |
二级信息参考文献 | Second level information references |
无 |
None |
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